Bђњthe difference on the seventh day was 0.

Antibiotics that doctors usually prescribed for sinus not reduce symptoms better than inactive placebo, according to investigators, the Washington University School of Medicine in St. Louis. BЂњPatients donBЂ ™ t better faster and have fewer symptoms when they get antibiotics BЂ "said Jay F. Piccirillo, MD, professor of otolaryngology and studyBЂ ™ s main author. BЂњOur results show that antibiotics arenBЂ ™ t need for primary sinusitis BЂ "most people better themselves. BЂ "

The results were published February 15

Journal of the American Medical Association. In the United States more than one in five antibiotics are designed to slot

indicate the authors. And given the growth of bacteria resistant to these drugs, they say that it is important to determine whether this treatment is effective. Their results show that it is not. Antibiotics BЂњWe feeling is abuse in primary care settings BЂ "says Jane M. Garbutt, MD, research assistant professor of medicine and first author paperBЂ ™ s. BЂњThere the movement in motion, led by the Centre for Disease Control and Prevention to try to improve the rational use of antibiotics. We hope that this study provides scientific evidence that doctors can use with patients to explain that antibiotics can not help acute sinusitis. BЂ "

In practice, instead of antibiotics such as amoxicillin are used in this study, researchers propose to treat symptoms such as pain, cough and congestion and waiting tactics or further treatment. The study included 166 adults, whose symptoms meet the criteria for acute sinusitis recommended by the panel convened by the Centers for Disease Control and Prevention. To participate, patientsBЂ ™ symptoms were to be classified as moderate, severe or very severe. In particular, they had to report pain or tenderness in the face and nose and nasal discharge, which lasted from seven to 28 days. Patients with chronic sinus infections or serious complications from conditions such as ear infection or simultaneous breast that were not included in the study. Patients were recruited in their primary health physiciansBЂ ™ offices in St. Louis and were randomized to receive 10-day course or amoxicillin or placebo. Not to amoxicillin or not, all patients received medication for pain, fever, congestion and cough. Researchers rated patientsBЂ ™ symptoms in the early treatment, then three, seven, 10 and 28 days thereafter. At each point in time, patients answered questionnaires assessing the quality of life measurement associated with the disease, called sinuses of test results 16 (snot-16). They also compared the recurrence of symptoms and days missed from work. On the third day, they found no difference between antibiotic and placebo in any of these events. On the seventh day, a slight improvement was seen in antibiotic groupBЂ ™ s assessment questionnaire. However, Garbutt says that this small change is hardly noticeable relief of symptoms. BЂњOn scale of 1 to 3, we estimate that clinically significant difference would change 0. 5 snot-16 scores BЂ «Garbutt said. BЂњThe difference on the seventh day was 0. 19. Although this was statistically significant changes itBЂ ™ will likely not change that the patient will not notice. BЂ "

In addition, this modest improvement of statistical gone ten days, when about 80 percent of patients in both groups reported that their symptoms were greatly improved or cured. They also found no difference between antibiotic and placebo in the amount of medication patients decided to use to relieve pain, fever, congestion and cough. BЂњItBЂ ™ SA nasty disease BЂ «Garbutt said. BЂњPeople significant symptoms. They feel unhappy and miss from work time. If the antibiotic is not purchase strattera any good, then what? ThatBЂ ™ SA issue that we havenBЂ ™ t answer. But we are working on it. BЂ. "